Low-dose Niacinamide has strong anti-bacterial effect

Niacinamide is a precursor to NAD+ (nicotinamide adenine dinucleotide), (an important signaling molecule believed to play an important role in longevity. In fact, the best single NAD+ precursor is niacinamide, and this is a reason to educate yourself about its benefits, but niacinamide, also known as nicotinamide (NAM), is also valuable in its own right.

For example, NAM supplementation has been found to improve insulin sensitivity in human diabetes models, and it also reduces oxidative stress and prevents fatty liver.^first It also shows impressive promise in combating obesity and related diseases, including stroke, cardiovascular diseases, diabetes and some cancers, which have reached epidemic proportions worldwide.²

But the important thing with NAM is that you need the right dose of “Goldilocks”. The most common mistake people make is taking too much and thus actually sabotaging any metabolic gains.

Niacinamide reprograms fat metabolism, improves obesity

NAD+ regulates energy production and many enzymes, thus, controlling hundreds of processes in your body, including cell survival and energy metabolism. NAD+ is affected on a daily basis by what you eat, exercise levels and more, and also declines with age, leading to changes in metabolism and an increased risk of disease.³

Increasing NAD+ levels can be like the fountain of youth, which is where niacinamide – a precursor to NAD + – comes in. More than 2 billion people worldwide are overweight, 35% of whom are severely obese.⁴ NAD+ has a notable role in obesity, with higher levels associated with the reduction of adipose tissue in obese rodents and humans.⁵

Writing in the Journal of Nutritional Biochemistry, researchers from Tsinghua University, Beijing, reveal that NAM reprograms fat cell metabolism and increases mitochondrial biogenesis to improve health. obesity status.⁶ In a study in obese rats, NAM supplementation resulted in a significant reduction in fat mass and improved glucose tolerance, while also increasing mitochondrial biogenesis in adipose tissue.⁷

Niacinamide activates NAMPT

In the study, NAM also activated the rate-limiting enzyme for NAD + NAMPT (nicotinamide phosphoribosyltransferase). Nichola Conlon, Ph.D., a molecular biologist, anti-aging expert and founder of a nutrition company that makes supplements that promote NAD+, explained in a previous interview. Here are ours:⁸

“The reason the rescue pathway decreases with age is because of one of these important enzymes. NAMPT actually recycles niacinamide and converts it into NMN [nicotinamide mononucleotide], which is then converted back to NAD. The rate-limiting step, the bottleneck in that process, is NAMPT. And hey, that’s an important enzyme that declines as we age.

Studies have proven that you reduce your intake of this enzyme by 50% between the ages of 45 and 60. That’s a significant decline considering how important this is for the production of new NAD. The decrease in the level of this enzyme again correlates with the decrease in NAD that we experience.

Many diseases and problems associated with NAD depletion have been found to be due to decreased levels of this enzyme. Therefore, it is paramount to try and improve the activation and expression of this enzyme in the body to enhance NAD. It works great to give us high levels of NAD when we are young, so why not restore it back to the way it is? “

Interestingly, recent research in obese rats confirmed the dosage I was recommending when I first posted three months ago. They found that the addition of NAM increased cellular NAD+ levels by 30% – and this was without the additional interventions I advised, such as exercise and restricted eating. time. The researchers note:⁹

“Unexpectedly, we found that NAM also increased glucose-derived amino acids to enhance glutathione synthesis to maintain cellular redox homeostasis. Taken together, our results demonstrated that NAM reprogrammed cellular metabolism, enhancing fat mitochondrial function to ameliorate obesity-related symptoms. “

In summary, research has revealed impressive benefits when supplementing with NAM at a low dose of 2.5 milligrams (mg) per kilogram of body weight daily for three weeks.^ten about 170 mg for a 150-pound person. I have recommended 50 mg three times a day. In addition to the increase in NAD+, they note:¹¹

Niacinamide is the best NAD+ precursor

During my research for my landmark book, “EMF’D,” I read dozens, if not hundreds, of articles on NAD+ and now realize that it is possible for financial gain. for which the best precursor – niacinamide – is not recommended more often.

The immediate breakdown product of NAD+ is niacinamide and the enzyme NAMPT is the rate-limiting enzyme in the lifesaving route to restoring niacinamide back to NAD+. As you can see by the pathway below, niacinamide is first converted to NMN before NAD+. This may be why researchers like David Sinclair with Harvard Medical School and others promote NMN.

However, the enzyme NMNAT1-3 that converts NMN to NAD+ is not a rate limiting enzyme. Recall that NAMPT is what controls how much NAD+ you generate. So, flooding your body with NMN won’t be as helpful as taking a small amount of niacinamide and activating NAMPT. The ideal dose of niacinamide is between 25 and 50 mg three times a day. This is the rare person who does not respond favorably to this simple intervention to increase NAD+.

Why You Haven’t Heard Of Niacinamide

When it comes to NAD+ precursors, chances are you haven’t heard of niacinamide, despite its powerful benefits, and this is because it costs much less than other NAD+ precursors, for example as nicotinamide riboside (NR).

No one advertises niacinamide because it costs less than a dime a day and as a result there is no money to advertise it. It’s best to buy powdered niacinamide and use 1 to half of one of sixty-four teaspoons three times a day (25 to 50 mg).

If you want a more precise dose, you can use the dose in the study of 2.5 mg/kg or 1.13 mg/pound of body weight in three divided doses per day. If you are a 150-pound person, this would be about 50 to 60 mg three times a day.

You will need a special measuring spoon to measure this small dose. This is very important, because more is definitely not better. If you use too much, you will actually inhibit sirtuins, which are important longevity proteins.

Spending $11 on 250 grams of niacinamide powder will give you almost four years’ supply. That number earns 23 cents a month – or less than a cent a day. It is basically free. NMN with therapeutic doses of 1 to 2 grams per day can be $100 to $200 a month, or 400 to 800 times more expensive than niacinamide powder.

Why is it important to increase NAD+ levels?

As mentioned, the reason why research on niacinamide is so exciting is that it seems to effectively and safely boost NAD+, which declines with age. In animal studies, restoring NAD+ levels in elderly or sick individuals promotes better health and prolongs life, which suggests that NAD-promoting molecules have the potential to increase recovery, reducing disease, and prolonging healthy life in humans.¹³

Research on NAD+ is still in its infancy, but James Clement, author of “The Switch: Ignite Your Metabolism With Intermittent Fasting, Protein Cycling, and Keto,” has conducted his own research, starting with a clinical trial testing intravenous NAD+ in the elderly, in collaboration with Dr. John Sturges.

Clement himself underwent treatment, which included an infusion of 1,000 mg of NAD+ per day for six consecutive days, and found it to be remarkably effective for the tremor he had suffered from the age of 20. While he believes 1,000 mg may be too much for people without severe NAD+ impairment — and also the high cost, at $1,000 per intravenous injection — he notes that many factors Lifestyle factors can lower your levels, including alcohol consumption.

Aging is another factor and, according to Clement, NAD+ can be depleted by 50% by the time you are 60 (compared to in your 20s or 30s) and by the time you are 70 you may have as little as 10% left. the amount that you. did when you were young.

“And then at 80, there’s almost none,” he says, adding that this will severely impair your body’s ability to repair damaged DNA. “You can see that the huge accumulation of damaged DNA in every cell of your body is potentially one of the drivers of the diseases you see like aging, heart disease, cancer. [and] Alzheimer … “

Natural ways to increase your NAD+

Niacinamide supplementation can be beneficial, but for best results, it should be taken in conjunction with a healthy lifestyle. There are many natural strategies you can implement to boost and maintain youthful NAD+ levels, including:¹⁴

• Do exercise – Increases NAMPT naturally by activating AMPK, thereby increasing NAD+. Conlon cites research showing that about three weeks of resistance training increases NAMPT by about 127%, again, a much larger number than what you can get with NR supplements alone.
• Fasting or time-restricted eating – Increases NAMPT naturally by activating AMPK, thereby increasing NAD+.
• Circadian rhythm optimizationby going to bed at dusk and waking up at sunrise and avoiding blue light after sunset, will have a profound effect on increasing NAMPT.
• Avoid exposure to radiation – To protect your NAD+ by preventing its consumption by PARP (poly ADP ribose polymerase), consider avoiding EMF in the form of cell phones, Wi-Fi, and other forms of DNA damaging radiation, such as medical X-rays and unnecessary CT scans.
• Sauna – Heat stress helps increase NAD+.

Testing NAD+ levels in the lab is difficult and complicated, and Conlon suspects that most companies that advertise NAD+ testing get accurate results. So how can you tell if the strategies you are using are really increasing your level or not? Pay attention to the following three items, which almost always improve as NAD+ levels increase, according to Conlon:¹⁵

1. Energy level, added “get up and go”
2. Mental clarity and focus
3. Sleep

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