Latest brain metastasis study could lead to new therapy, uncovering cause behind brain tumor

Although several immunotherapies have been shown to be effective in treating metastatic melanoma, researchers still don’t know the reason behind the tumor’s spread to the brain. Now, through an extensive study of the cells inside metastatic brain melanoma, researchers have elucidated the details of the condition that could lead to the development of new therapies.

Melanoma is a type of skin cancer and Brain Metastasis is a condition that occurs when cancer spreads from its original site to the brain. Brain metastases are behind most cancer-related deaths and most cases have been documented with advanced malignancies.

inside researchpublished year Cell, researchers from Columbia University Irving Medical Center began by sourcing frozen metastatic tumors from dozens of melanoma patients. “Such studies are often performed on fresh brain samples, which are in short supply, significantly limiting the number of tumors that can be analyzed. In contrast, we have many frozen melanoma samples in our tissue bank.” speak Research leader Benjamin Izar, MD, PhD, and assistant professor of medicine at the university.

Izar added that the technique allows them to see the biology of the tumor and its microenvironment by helping them analyze tissues from untreated patients. After analyzing genes in more than 100,000 individual cells, the researchers noted that brain metastatic melanoma is more chromosomally unstable than melanoma metastases in the other parts of the body.

According to Johannes C. Melms, MD, a molecular postdoctoral fellow at the Izar lab and one of the study’s first authors, chromosomal instability triggers pathways Signaling facilitates the spread of cells and suppresses the immune system.

“Several experimental drugs that reduce chromosomal instability will soon be tested in humans. We now have the facility to evaluate these drugs in patients with metastatic melanoma in the brain,” Melms said.

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