A strange outbreak of severe hepatitis in young children has been reported in the US and Europe, confusing public health officials. The children were tested for common hepatitis viruses but were not blamed, the cause was unknown.
In a press release, Graham Cooke, professor of infectious diseases at Imperial College London, suggested that if hepatitis was caused by COVID-19, it “would be surprising how widely distributed it is.” nationwide with a high prevalence of (COVID-19) at the moment. ”first
Potential links to COVID-19 injections appear to remain largely unexplored, although these injections have previously been implicated in the development of hepatitis.2 However, UK health officials have stated that none of the children affected have been vaccinated with COVID-19.3
Young children develop mysterious liver disease
In the US, nine children in Alabama developed severe hepatitis, or hepatitis, that health officials could not explain. All children were 6 years of age or younger and were previously healthy.4 Symptoms of liver disease include diarrhea, nausea, and vomiting, along with jaundice in some people. Liver enzymes are also elevated.
Five of the children tested positive for adenovirus type 41, a respiratory virus that can cause the common cold. Health officials have suggested that adenovirus type 41 could be the cause, but Dr Wes Stubblefield, county health officer for the Alabama Department of Public Health, admitted to NBC News, “This is unusual. Previously, this virus was not associated with the signs, symptoms and injuries of this constellation. “5
Others have also rejected this theory, since adenoviruses are extremely common in children, meaning they could most likely test positive for adenoviruses without them being the cause of their hepatitis.6 As of April 8, 2022, 74 cases of hepatitis have been reported in children under 10 years of age. Several children were hospitalized and six received liver transplants, but no deaths have been reported as of April 11, 2022.
With the increase in cases reported last month, the World Health Organization expects more cases of the mysterious hepatitis in children to be discovered. To date, laboratory testing has ruled out hepatitis A, B, C, and E viruses, along with hepatitis D if present.
“Overall,” the WHO reports, “the etiology of hepatitis cases is currently considered unknown and is still under active investigation. Laboratory testing for additional infections, chemicals and toxins is underway for the identified cases.”7
Shooting COVID-19 can cause hepatitis
A case report involving a 47-year-old, formerly healthy man demonstrates convincing evidence that injection of COVID-19 can induce hepatitis. “Immune-mediated hepatitis with Moderna vaccine,” the researchers wrote in the October 2021 Journal of Hepatology, “[is] It is no longer a coincidence that has been confirmed”.8
The man featured in the case report received the first Moderna COVID-19 shot on April 26, 2021. Three days later, he developed malaise and jaundice, which can occur. out if your liver does not process red blood cells efficiently ; it is a sign of hepatitis, and a symptom that some of the children above have experienced.
The man had his liver function checked four years earlier, with tests returning to normal and no history of acetaminophen use, which can cause liver damage, and only minimal alcohol use . However, three days after the injection, liver tests showed disturbing results:9
“Investigations on April 30 showed serum bilirubin 190 μmol/L (normal 0-20), alanine aminotransferase (ALT) 1,048 U/L (normal 10-49), alkaline phosphatase (ALP) 229 U/L (normally 30-130 )…”
At the end of June, the man’s jaundice and liver function tests improved, but he was then given a second injection of Moderna on July 6, 2021. Within days, the condition Jaundice returned and liver function tests decreased. The histological appearance of the lesion is consistent with acute hepatitis, with features of autoimmune hepatitis or drug-induced liver injury (DILI), causing autoimmune hepatitis, the researchers explain. translation,” the researchers explain further:ten
“This case illustrates immune-mediated hepatitis secondary to Moderna vaccine, where accidental re-exposure resulted in more severe liver injury with impaired synthetic function. This happens in a good man with no other medical problems. The onset of mRNA vaccine-associated jaundice is unusually rapid.”
Cases of hepatitis reported after scans
The above case report is not an isolated report. The Journal of Hepatology notes that seven other suspected cases of immune-mediated hepatitis have been reported following COVID-19 injections, including Pfizer and Moderna.
They hope to raise awareness so that immunization centers will regularly check for signs of immune-mediated hepatitis before the second dose, and state: “The long-term follow-up of individuals identified will be essential in determining the prognosis of this immune-mediated liver injury. ”11
In a separate letter to the editor, published in the June 2021 issue of the Journal of Hepatology, the researchers again raised concerns that the COVID-19 shots could cause hepatitis. . In this case, a 56-year-old woman developed severe autoimmune hepatitis after receiving the first dose of Moderna’s COVID-19.twelfth
Previously, in April 2021, researchers also described a case of autoimmune hepatitis that developed after a COVID-19 injection, this time in a 35-year-old woman three months after giving birth. In autoimmune hepatitis, the body’s immune system mistakenly attacks the liver, causing inflammation and damage, and it is possible that the drug has triggered the autoimmune process through mutant antibodies. variable:13
“To our knowledge, this is the first reported case of autoimmune hepatitis that develops following COVID-19 vaccination, raising concerns about vaccine-induced autoimmunity. Since a causal relationship cannot be proven, it is possible that the association is purely coincidental.
However, severe cases of SARS-CoV-2 infection are characterized by autoinflammatory dysregulation that contributes to tissue damage. Since the viral spike protein appears to be responsible for this, it is plausible that mutant-directed antibodies produced by vaccination could also induce autoimmune conditions in predisposed individuals. sick. “
Is the lack of immunity to blame?
Researchers from Ireland noted in November 2021, “It is speculated that SARS-CoV-2 may disrupt self-tolerance and trigger autoimmune responses through cross-reactivity. with host cells and the COVID-19 mRNA vaccine could trigger a similar response.” They also reported the cause of autoimmune hepatitis that developed following a COVID-19 shot in a 71-year-old woman with no risk factors for autoimmune disease.
She noticed jaundice four days after the injection and had “significantly abnormal” liver function tests. The researchers raised the possibility that this was a case of vaccine-related drug-induced liver injury, and like other groups that have reported similar cases, note:14
“These findings raise the question of whether vaccination with COVID-19 mRNA could, through activation of the innate immune system and subsequent nonspecific activation of self-active lymphocytes, lead to to the development of autoimmune diseases including AIH or drug-induced liver injury with or without AIH features.
Triggers, if present, may become more apparent over time, especially after immunosuppression is discontinued. As with other vaccine-related autoimmune diseases, causality or casualty will be difficult to distinguish… But it raises the question of whether these people should receive a second dose of the COVID-19 mRNA vaccine- 19 or not. ”
Stephanie Seneff, a senior research scientist at the Massachusetts Institute of Technology (MIT), and colleagues also highlighted the innate immune suppression triggered by COVID-19 shots.15
COVID-19 mRNA shots teach your cells to produce a protein, or protein fragment, that triggers an immune response, including antibody production.16 However, because natural mRNA is easily disrupted, this means that the experimental gene therapy needs a special delivery system to get it to the body’s cells.
Photographs using lipid nanoparticles containing polyethylene glycol (PEG)17 for this purpose. The mRNA is wrapped in lipid nanoparticles (LNPs) that carry it to your cells, and the LNPs are “PEGylated” – that is, chemically attached to PEG molecules for increased stability.18
Normally, if you inject RNA into your body, enzymes break it down right away, but the COVID-19 shots are specifically designed so that doesn’t happen. Thus, “mRNA vaccines promote sustained synthesis of the SARS-CoV-2 mutant protein,” Seneff and colleagues write in the Journal of Food and Chemical Toxicology.19They explain that the mutant protein is not only neurotoxic but also impairs DNA repair mechanisms, while inhibition of the type I interferon response leads to impaired innate immunity.20
Disturbances due to the effects of COVID can cause liver disease
Seneff’s research shows that genetic changes introduced by COVID-19 shots can cause immune cells to release large amounts of exosomes into the circulation. Exosomes are extracellular vesicles containing proteins, DNA, RNA, and other components, and may contain mRNA along with spike proteins. According to Seneff et al:21
“[W]e presents evidence that vaccination induces severe impairment in type I interferon signaling, with various adverse consequences on human health. Immune cells that administered the vaccine nanoparticles released into the circulation a large number of exsomes containing the mutant protein along with important microRNAs that induce signaling responses in recipient cells at sites distant mind.
We also identify potentially profound perturbations in the control of protein synthesis regulation and cancer surveillance. These disorders may have a causal link with neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell’s palsy, liver disease, impaired adaptive immunity, impaired damage response DNA damage and tumor formation. “
In one example documented in their study, the injection appeared to have caused a reactivation of the virus leading to liver failure. This case involves an 82-year-old woman who developed hepatitis C (HCV) in 2007. Just a few days after she was injected with Pfizer COVID-19, “HCV levels rose sharply,” along with jaundice. She died of liver failure three weeks after the injection.22
They also reported that the release of microRNA-containing exosomes after COVID-19 capture could interfere with IRF9 synthesis, leading to decreased synthesis of sulfates in the liver. They believe this cascade may represent a “reasonable factor” in the many reported cases of detected liver damage following a COVID-19 injection.23
When they reviewed data from the Vaccine Adverse Event Reporting System (VAERS), which included symptoms that were “clearly indicative of serious liver problems,” they identified the following 731 events: with COVID-19 injections – accounting for more than 97% of all vaccines by 2021.24
Pfizer documents released by the US Food and Drug Administration in April 2022 must also be taken into account. Buried in one of the documents is the statement, “Clinical laboratory evaluation showed that a transient decrease in lymphocytes was observed in all age and dose groups after Dose 1, finished in about a week…”25
This means that Pfizer knows that, during the first week after injection, people of all ages experience transient immunosuppression, or, in other words, a temporary weakening of the immune system after the first dose. Could this increased susceptibility to infection play a role in hepatitis and other cases of liver disease following vaccination? An investigation is guaranteed to find out.
