Health

Rapid vitamin D delivery may lead to better COVID outcomes


Since the start of the pandemic, natural supplements have been the target of controversy with researchers, pharmaceutical companies, doctors and health professionals. New data publishedfirst once again supports previous research that vitamin D has a significant impact on COVID-19.

Vitamin D was discovered in the early 1900s. The work of Sir Edward Mellanby from the UK and Elmer McCollum from the University of Wisconsin demonstrated that vitamin D can cure rickets.2 In the early 1970s, 25-OH-D3 was identified by scientists as focusing on the endocrine system and vitamin D function in the body.

Your body is capable of producing vitamin D when exposed to sunlight.3 In fact, with adequate exposure, your skin can produce enough vitamin D to support your health. Early research shows that too little vitamin D leads to poor calcium homeostasis. In turn, this can lead to osteoporosis, osteomalacia, and rickets.

Experiments4,5 It has since been shown that deficiency “is associated with an increased risk and severity of infections, particularly in the respiratory tract.”6 Although nearly every study has found a link between vitamin D and upper respiratory tract infections, not all have found that vitamin D has an equal impact on infections. .

One factor that could influence the different outcomes is how the researchers measured the intervention and the data. In other words, are they measuring the amount of the supplement given, or are they looking at blood levels of vitamin D demonstrating a deficiency to fight the effects of infection?7

Research shows that Vitamin D reduces COVID and reduces mortality

Research8 was published in November 2021 to determine if vitamin D could play some role in the treatment of COVID-19. The researchers note that patients admitted to the intensive care unit have high plasma biomarkers that indicate inflammation. They wrote:9

“Given the natural three-stage clinical course of the disease, an inadequate innate immune response in the early stages and immune-mediated injury from a dysregulated immune response in the second phase. considered to be the main determinants of poor outcomes.”

If a supplement or drug can support the immune response in the first or second phase, it can help reduce the severity and mortality of the disease. First, the researchers collected retrospective data from 867 patients at the Cerrahpasa Faculty Hospital of Istanbul University.

Patients had a confirmed diagnosis of COVID-19 but were excluded from the cohort if they had comorbidities associated with vitamin D deficiency, such as cancer, kidney disease, cardiovascular disease, or autoimmune diseases. immunity. Each patient received antiretroviral therapy and some received anti-cytokine therapy. Clinical outcomes were measured based on serum vitamin D status.

In the retrospective arm of the study, the researchers divided the participants into four groups determined by their serum 25OHD levels. Data from this group showed a 1.9-fold higher risk of hospitalization for longer than 8 days in patients in 3 of the groups.

The second part was designed as a prospective study involving 210 people with confirmed COVID-19. The researchers included 23 healthy people. In this group there were 163 participants with a serum 25OHD level below 30 ng/mL. These subjects were treated with vitamin D3 according to a regimen created by reviewing evidence from the previous literature.

The researchers used vitamin D3 based on whether the patients were inpatients or in the ICU and which group they were in. The total duration of vitamin D administration ranges from 14 days for inpatients to 3 days for ICU patients.

The researchers measured peripheral blood samples in all of their patients on Days 1 to 3 prior to treatment and on Days 7 and 14 in those treated. Participants in the prospective cohort were also treated according to current national guidelines, which at the time did not recommend vitamin D supplementation.

The treatment regimen increased the serum 25OHD level to above 30 ng/mL significantly within two weeks in the intervention subjects. They found that vitamin D treatment shortened hospital admissions in people with COVID-19, even in the presence of comorbidities. They concluded:ten

“Treatment with vitamin D reduced mortality by 2.14 times. It has been established that vitamin D supplementation is effective across various target parameters; it is therefore an important parameter for the course of COVID-19, and serum vitamin D concentrations and correlation analyzes between these parameters confirm this inference. “

More evidence Vitamin D affects COVID outcomes

There is strong scientific evidence that vitamin D plays a central role in your immune response and ability to fight infections. In this video, Ivor Cummins, biochemist and director of the Irish Heart Disease Awareness program, explains how recent studies support higher vitamin D levels can reduce the risk of negative outcomes from COVID-19.

He also identified several conditions known to be associated with low vitamin D levels. These include low sun exposure, insulin and leptin resistance, high levels of inflammation, and a poor diet. A study evaluating Cummins was released by Mark Alipio, who received no funding for his work.11

The data are an analysis of 212 people with laboratory-confirmed COVID-19 and those with serum 25OHD levels. Alipio used a previous research-based classification system similar to the four used in the Emerging Nutrients study. The difference is that the two categories from prominent research are combined, but the classification of the other two remains the same.

Alipio found that vitamin D levels were strongly correlated with disease severity. As you can see in the image Cummins used from the study at 2:20 min in the video above, out of 49 people with mild illness, 47 had vitamin D levels above 30 ng/mL. It is important to note that most experts consider this to be roughly half of the optimal vitamin D level, which is 40ng/mL to 60ng/mL.twelfth

This means that 96% of patients with mild disease have normal vitamin D levels.13 Of the two remaining categories that combined severe or critical illness, only 4% had normal vitamin D levels.

An early study14 hypothesized that vitamin D protects the body against SARS-CoV-2 infection and sought to assess whether there was an association between vitamin D levels and the number of COVID-19 cases. The data included only European countries and found a significant relationship between mean (mean) vitamin D levels and number of infections.15

People who are most susceptible to these respiratory infections are the ones who are most deficient. Another early study evaluating the role of vitamin D deficiency in preventing respiratory infections found similar results.16 The researchers wrote that vitamin D has:17

“…A significant protective effect when it was given daily or weekly to people with the lowest vitamin D levels: the risk of at least one episode of ARI was reduced from 60% to 32% in these people.”

Subsequent studies throughout 2020 and 2021 added more evidence that vitamin D has a significant effect on the severity and mortality of people with COVID-19 and may help reduce rates hospitalize.

Low vitamin D is associated with increased inflammatory cytokines and an increased risk of pneumonia and respiratory infections.18

Vitamin D affects the regulation of inflammatory flow, and deficiency is associated with “increased risk of infections including influenza virus, tuberculosis (TB), human immunodeficiency virus (HIV), and recent outbreak of severe acute respiratory syndrome coronavirus 2” (SARS-CoV)-2). “19

Vitamin D deficiency increases the risk of severe COVID-19 and death.20

Vitamin D reduces inflammation caused by T cells, which may benefit people with COVID-19.21,22

The literature review found that serum vitamin D levels were associated with risk of infection, severity of illness, and death from COVID-19.23

Vitamin D deficiency is associated with increased risk of infection, severity of illness, and death from COVID-19; presented at the 2021 Annual Meeting of the American Society for Bone and Mineral Research.24

The data showed that 83% of 11,901 patients from 23 studies were deficient or inadequate in vitamin D, making the incidence 3.3 times higher and the development of severe disease 5 times higher in those with shortage.25

The active form of vitamin D can inhibit the replication of SARS-CoV-2, the virus that causes COVID-19.26,27

Vitamin D deficiency in 489 patients increased the risk of testing positive by 1.77 times compared with those with adequate levels. A deficiency is defined by a 25OHD level below 20ng/mL.28

Bolus vitamin D supplementation in frail elderly immediately before or during COVID-19 is associated with better survival rates and less severe disease.29

Research has demonstrated an association between vitamin D deficiency and severity and mortality from COVID-19.30

Vitamin D supplements may prevent COVID-19 or treat it in adults and children.thirty first

The Top Signs You Might Have a Vitamin D Deficiency

The only way to definitively determine vitamin D deficiency is with a blood test. However, there are some general signs and symptoms that suggest you should get a vitamin D test sooner rather than later.

  • Musculoskeletal pain or persistent bone pain32
  • Illnesses or frequent infections33
  • neurological symptoms,34 including depression35
  • Fatigue and daytime sleepiness36,37
  • Sweating head38

One of the easiest and most cost-effective ways to measure your vitamin D levels is to participate in GrassbaseHealth’s Action D*,39 is a population intervention vitamin D program. The test is done in the convenience of your home and the results are sent directly to you.





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